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Whitepapers, Posters & Presentations

White Papers

  • Stability of Plasmid DNA - A Review of the Data

    A review of stability data for plasmid pharmaceuticals accross typical storage temperatures and handling conditions.

  • Comparison of VGXI’s HD and GMP Services

    Side by side comparison of the differences between VGXI’s Highly Documented (HD) grade and full cGMP grade service levels for plasmid production.

  • Purity by A260/280

    In-depth review of the standard test method and inherent limitations for evaluating nucleic acid purity.

  • Determining Plasmid Quantity for your Clinical Trial

    Case studies are presented to illustrate how much plasmid is required at each stage of manufacturing – from bulk production through fill/finish and product stability studies.

  • 5 Qualities to Look for in a CMO

    A review of five key qualities to look for when choosing a CMO to manufacture plasmid DNA for a clinical trial.

  • Plasmid DNA Manufacturing Timeline

    An overview of the typical steps and time required for completion of a GMP plasmid manufacturing campaign.

  • Kanamycin Concentration Reduction During the VGXI Process

    This white paper reviews how a common plasmid selection agent, Kanamycin, is removed during the VGXI purification process to levels that are undetectable by standard assay methods.

  • Single-Use Process Equipment

    White paper reviewing process and quality improvements possible through the use of single-use systems in biopharmaceutical manufacturing.

  • VGXI Pre-Clinical Production Service

    VGXI’s Pre-Clinical Production Service uses the same patented manufacturing technology as our GMP production.

  • VGXI HD Plasmid Production Service

    VGXI’s HD Production Service produces plasmids suitable for use as a raw material in cGMP viral vector manufacturing and toxicology studies.

  • VGXI cGMP Production Service

    VGXI's cGMP Production Service provides injectable-grade plasmid DNA suitable for human clinical trials and commercial supply.

Posters & Presentations

    • ASGCT 2017 Poster Presentation

      Novel Method for RNA Quantification and Exclusion from Plasmid DNA Vector Purification Process Stream

    • ASGCT 2016 Poster Presentation

      Challenges of Production of Nanoplasmid™ with Large Gene Insert Using the HyperGRO™ Fermentation Process

    • ASGCT 2015 Poster Presentation

      High Quality Plasmid DNA Manufacturing for Ex-Vivo Protein Synthesis and Viral Vector Production for Gene Therapy

    • ASGCT 2014 Poster Presentation

      Large Scale Production of DNA Plasmids with Complex Gene Inserts

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281-296-7300
2700 Research Forest Drive, Suite 180
The Woodlands, Texas 77381, USA

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