US-Based Plasmid Manufacturing

US-Based Plasmid Manufacturing Simplify Your Supply Chain

Manufacturing Excellence

Manufacturing Excellence for Next-generation Therapeutics

Plasmid DNA Manufacturing

The World’s Largest Capacity for Plasmid DNA Manufacturing

VGXI is a leading-edge CDMO dedicated to revolutionizing the biopharmaceutical industry with best-in-class nucleic acid-based products and services. We deliver manufacturing excellence in state-of-the-art facilities with the agility and scale to meet projects of all sizes to serve the global community of next-generation therapeutic developers.

Pre-clinical Plasmids

HD Plasmids

cGMP Plasmids

Manufacturing Services

Pre-clinical Plasmids

Pre-clinical Plasmids Icon

VGXI’s Pre-clinical Plasmid Production Service provides high purity plasmid preparations for early research, in vivo animal studies, and preclinical assessments for advanced therapies.

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HD Plasmids

HD Plasmids Icon

VGXI’s Highly Documented (HD) Plasmid Production Service provides high supercoil, low endotoxin plasmids for use as an ancillary raw material in cGMP manufacturing and IND enabling studies.

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cGMP Plasmids

cGMP Plasmids Icon

VGXI’s cGMP Plasmid Production Service produces injectable-grade plasmid DNA for human clinical trials, diagnostic reagents, and the GMP production of cell and gene therapies.

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Manufacturing Services

Manufacturing Services Icon

Our end-to-end solutions include Process Development & Optimization, Tech Transfer Support, GMP Cell Banking & Testing, Bulk Stability Testing, Fill/Finish Services, Product Stability Testing, Rapid TAT Manufacturing, and RNA Production.

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Plasmid DNA Applications


Plasmid DNA plays a critical role in the development and production of next-generation therapeutic modalities including gene therapies, personalized cell therapies, mRNA-based therapeutics, and DNA vaccines. These applications all rely on plasmid DNA, which can be genetically engineered to encode viral vector elements, CRISPR/Cas9 components, and other sequences, for delivery into target cells. Our proven expertise in plasmid production has been instrumental in propelling these advanced therapeutics forward. We are dedicated to supporting our clients now and into the future to bring innovative treatments to market to help patients in need worldwide.

Gene Therapy

Gene therapy is a cutting-edge approach that aims to treat or cure diseases by replacing or inactivating disease-causing genes or introducing new or modified genes to treat or cure diseases.

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Cell Therapy

Gene-modified cell therapy or ex vivo gene therapy involves genetically modification of cells outside the body before infusion into the patient to combat diseases, such as in Chimeric antigen receptor T-cell (CAR T-cell) therapy used for treating certain hematologic cancers.

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Immunotherapy & Vaccines

Immunotherapy and nucleic acid vaccines prevent and/or treat diseases by enhancing the immune system's ability to launch potent immune responses to target pathogens and cancer cells.

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Plasmid Manufacturing Quality and Testing


With a strong customer-centric approach, VGXI brings two decades of expertise delivering exceptional products and services to the global market. Our capabilities are diverse, encompassing plasmid manufacturing in our state-of-the-art facilities, analytical testing, tech transfer, process development, quality management, and comprehensive regulatory expertise. We prioritize customer satisfaction and firmly believe that when our clients succeed, we succeed.

VGXI has been a great partner in our development program. They have been extremely reliable, flexible, and responsive to our GMP and clinical trial needs, both in the US and abroad. VGXI has been critical to our current success with regulatory agencies and clinical trial support.

Sr. Director
R&D Operations
Early Phase Biotech Company

Since day one, the team at VGXI listened carefully to our priorities and was able to deliver on a very aggressive timeline. With high focus on product quality, efficiency, and customer service, everyone on the team worked together to deliver on an accelerated timeline.

Alliance Management
Late Phase Gene Therapy Company

Thank you to the VGXI team for your efforts this year. You run a really professional ship and there has been a great deal of trust build up between VGXI and [our company] over this time. Your flexibility and attention to detail has been second to none.

CMC Lead

Large Pharma Company

After using VGXI for plasmid manufacture for over three years, I would have no hesitation in recommending them. The technical staff are knowledgeable and products are manufactured to schedule. Perhaps more importantly, VGXI are flexible to their clients’ needs and their Customer Service is excellent.

Christine Carrington
Programme Director
Cancer Targeting Systems, Inc.


Read Our Latest Blog Post

Check out the VGXI blog where we examine scientific trends, innovation, technological advancements in plasmid DNA manufacturing, and uncover how next-generation therapeutics are shaping the future of medicine and improving patients’ lives.