Careers at VGXI

If you are driven by innovation, fueled by scientific curiosity, and committed to making a positive impact on the global pharmaceutical community, you’ve come to the right place. We are always looking for quality-minded, team-oriented individuals who share our dedication to excellence. At VGXI, we’ve cultivated a workplace that people genuinely enjoy being a part of, and we take immense pride in the role they play in shaping our success story. We embrace a culture of quality in our products and in our people. Explore the possibilities, unlock your potential, and contribute to the future of Plasmid DNA manufacturing and precision medicine with VGXI.

Manufacturing Supervisor

Responsible for coordinating effort within the Manufacturing Team to manufacture revolutionary clinical and commercial nucleic acid-based pharmaceuticals by interfacing with manual and automated production systems and controls in cGMP manufacturing environment while maintaining areas in a state of compliance with internal quality systems. Ensure personnel are trained and follow standard operating procedures to safely operate production equipment for manufacturing operations. Maintains records, processes, and clean room environments to comply with regulatory requirements utilizing current Good Manufacturing Practices (cGMP) and Standard Operating Procedures (SOP). Identify, evaluate, test, and implement new technologies for process improvements.  Responsible for the implementation of current Good Manufacturing Practices (cGMP) in production areas. Responsible for proficiency in assigned functional areas. Understands and applies biological, chemical, and mechanical principles and techniques.

 

ESSENTIAL DUTIES AND RESPONSIBILITIES include the following. Other duties may be assigned.

  • Manufacture plasmid DNA conforming to GMP guidelines and VGXI SOPs.
  • Executes production plan by assigning personnel, accomplishing work results, establishing priorities, monitoring progress, and reporting results of the processing flow to Manufacturing Management.
  • Qualified in all processes involved in the manufacture of plasmid DNA and able to train and explain technical aspects of manufacturing processes to junior staff.
  • Specify and procure appropriate equipment as needed.
  • Install, commission and troubleshoot equipment as needed.
  • Interface with other operational departments to facilitate scale-up and technology transfer to meet growing demands.
  • Write and review Standard Operating Procedures (SOP) and production batch records.
  • Implement new equipment and processes for the manufacture of plasmid DNA.
  • Mentor junior staff and support team growth through the supervision of assigned projects.
  • Ensure continuous improvement initiatives and foster innovation within the Manufacturing staff.

 

EDUCATION and/or EXPERIENCE

Bachelor’s Degree (B.S.) or equivalent; or three to five years related experience and/or training; or equivalent combination of education and experience.

Quality Control Analytical Chemist

The Analytical Chemist is responsible for new assay development, method transfers, assay qualifications and validations. It is also the responsibility of this position to troubleshoot any problems that may arise and to be up-to-date on all methods applicable for QC use. QC Analytical Chemist will also participate in testing of products manufactured at VGXI.

 

ESSENTIAL DUTIES AND RESPONSIBILITIES include the following. Other duties may be assigned.

  • Knowledge and experience in developing and validating methods utilizing liquid chromatography (HPLC/UPLC, CGE and LCMS) is required.
  • Experiments may range from analyses using HPLC, CGE, Spectrophotometer, ELISA Assays, Gel Electrophoresis, and other instrumental methods to non-instrumental methods (wet chemical methods).
  • Knowledge of departmental procedures and policies.
  • Train junior staff on assays and GMP Practices.
  • Able to work in a fast-paced environment.
  • Day-to-day operations of the Quality Control Laboratory including testing, documentation and laboratory maintenance.
  • Support performance targets for the laboratory, and monitor actual performance against targets, taking appropriate and timely CAPA where applicable.
  • Support awareness and achievement of all regulations.
  • Provide technical support to the manufacturing team regarding issues which arise and are detected in the laboratory and also for trials which are performed as part of Root Cause investigation.
  • Support all Process and Equipment Validation projects where laboratory services are required.

 

EDUCATION and/or EXPERIENCE

Bachelor’s Degree (B.S.) or equivalent; or five to seven years related experience and/or training; or equivalent combination of education and experience.

Quality Control Technician

The Quality Control Technician is responsible for in-process, release and stability testing of products manufactured at VGXI. Responsibilities also include raw material testing. Set-up, organization, and day-to-day operations of a Quality Control Lab are also required.

 

ESSENTIAL DUTIES AND RESPONSIBILITIES include the following. Other duties may be assigned.

  • Experiments may range from analyses using Spectrophotometer, ELISA Assays, Gel Electrophoresis, qPCR, HPLC, CGE and other instrumental methods to non-instrumental methods (wet chemical methods).
  • Knowledge of departmental procedures and policies.
  • Able to work in a fast-paced GMP environment.
  • Day-to-day operations of the Quality Control Laboratory including testing, documentation and laboratory maintenance.
  • Support performance targets for the laboratory, and monitor actual performance against targets, taking appropriate and timely CAPA where applicable.
  • Support awareness and achievement of all regulations.
  • Provide technical support to the manufacturing team regarding issues which arise and are detected in the laboratory and also for trials which are performed as part of Root Cause investigation.
  • Support all Process and Equipment Validation projects where laboratory services are required.

 

EDUCATION AND/OR EXPERIENCE

Bachelor’s Degree (B.S.) or equivalent; or three to five years related experience and/or training; or equivalent combination of education and experience

Environmental Monitoring Technician

The primary responsibility of the Environmental Monitoring Technician is to perform all EM monitoring and related testing; water sampling, gas sampling and testing. Set-up, organization, and day-to-day operations of a Quality Control Lab are also required.

 

ESSENTIAL DUTIES AND RESPONSIBILITIES include the following. Other duties may be assigned.

  • Monitoring activities include but not limited to Non-viable air-borne, viable
  • Sampling and testing of WPU, WFI, process gases, Microbial testing, TOC and other wet chemical testings.
  • Able to work in a fast-paced GMP environment using aseptic techniques.
  • Working knowledge of trending software
  • Knowledge of departmental procedures and policies.
  • Day-to-day operations of the Quality Control Laboratory including testing, documentation and laboratory maintenance.
  • Support performance targets for the laboratory, and monitor actual performance against targets, taking appropriate and timely CAPA where applicable.
  • Support awareness and achievement of all regulations.
  • Provide technical support to the manufacturing team regarding issues which arise and are detected in the laboratory and also for trials which are performed as part of Root Cause investigation.
  • Support all Process and Equipment Validation projects where laboratory services are required.

 

EDUCATION AND/OR EXPERIENCE

Bachelor’s Degree (B.S.) or equivalent and two to five years related experience and/or training; or equivalent combination of education and experience. Preferred experience with execution of cleaning validations and of EMPQ.

Upstream & Downstream Manufacturing Process Technician

Responsible for manufacturing revolutionary clinical and commercial nucleic acid-based pharmaceuticals by interfacing with manual and automated production systems and controls in cGMP manufacturing environment while maintaining areas in a state of compliance with internal quality systems. Follows standard operating procedures to operate production equipment for upstream/downstream operations. Maintains records, process, and clean room environment to comply with regulatory requirements utilizing current Good Manufacturing Practices (cGMP) and Standard Operating Procedures (SOP). Responsible for proficiency in assigned functional area: Upstream/Downstream Manufacturing. Understands and applies biological, chemical, and mechanical principles and techniques.

 

ESSENTIAL DUTIES AND RESPONSIBILITIES include the following. Other duties may be assigned.

  • Manufacture plasmid DNA conforming to GMP guidelines and VGXI SOPs.
  • Upstream: Follow production records or SOPs and accurately document work to conduct cell banking, fermentation, and lysis processes for plasmid DNA manufacture                                                                                                                                                                                                                      or
  • Downstream: Follow production records or SOPs and accurately document work to conduct chromatography, filtration, aseptic processing, and product formulation and filling for plasmid DNA manufacture.
  • Perform work following aseptic processing guidelines as appropriate.
  • Prepare solutions required for the production process (media and buffer make-up).
  • Clean, assemble, and sterilize equipment for production by operating glass washers and autoclaves.
  • Write or Revise Standard operating procedures.
  • Install, commission and troubleshoot equipment as needed.
  • Responsible for documentation and maintenance of equipment, such as: documenting new equipment and equipment changes, conducting and documenting PM as required, ensuring proper documentation of equipment repair, etc.
  • Perform daily cleaning and sanitization of Production Areas.

 

EDUCATION and/or EXPERIENCE

Bachelor’s or Associate’s degree or equivalent from college or technical school; or one to three years related experience and/or training; or equivalent combination of education and experience.

Benefits

At VGXI, we recognize that our employees are at the heart of our success, and we offer exceptional benefits that reflect our commitment to their well-being. Our comprehensive offerings include a range of quality benefits, available to our employees from day one (no waiting period). Benefits include:

  • Medical
  • Dental
  • Vision
  • Life Insurance
  • Short-Term and Long-Term Disability
  • 401K Plan
  • Flexible Spending Account
  • Tuition Reimbursement
  • Paid Time Off Including Holidays, Vacation and Sick/Personal Leave

Diversity, Equity and Inclusion

At VGXI, we are committed to recognizing and valuing you. Our diverse backgrounds, perspectives, and contributions fuel innovation and allow us to success both as individuals and as a team. We have established and embrace a culture of acceptance and inclusion with equity in recruiting, hiring, developing, and investing in talented people. Our commitment to these principles supports a diverse workforce and empowers us to achieve our mission of leading the industry in producing the next generation of therapeutics to improve patients’ lives.